ChemicalBook CAS DataBase List 4,4'-METHYLENEBIS(2,6-DIMETHYLPHENOL)

4,4'-METHYLENEBIS(2,6-DIMETHYLPHENOL) synthesis

13synthesis methods

Product Name:4,4'-METHYLENEBIS(2,6-DIMETHYLPHENOL)
CAS Number:5384-21-4
Molecular formula:C17H20O2
Molecular Weight:256.34

50-00-0 Synthesis

50-00-0
846 suppliers
$10.00/25g

576-26-1 Synthesis

576-26-1
332 suppliers
$10.00/25g

5384-21-4
81 suppliers
$50.00/500mg

Yield: 94%

Reaction Conditions:

with silica supported perchloric acid in neat (no solvent) for 4.25 h;Catalytic behavior;Heating;Green chemistry;Reagent/catalyst;Solvent;

Steps:

Typical procedure for preparation of bisphenols
General procedure: To a stirred mixture of phenol (16.39 mmol) and aldehyde or ketone (16.39 mmol) was added HClO4-SiO2 (640 mg, 2 mol %) over a period of 15 min at 60 C and the mixture was further stirred for the appropriate time at the given temperature (Table 4). After completion of the reaction (TLC), ethyl acetate (50 ml) was added and the catalyst was separated by filtration. The filtrate was concentrated on a rotary evaporator under reduced pressure to give crude product which was purified by column chromatography over silica gel to furnish pure bisphenols in good to excellent yields (Table 5). The structures of known products were confirmed by 1H NMR, mass analysis and comparison of melting points with those reported in the literature. The data for the novel compounds are given below.

References:

Deota, Pradeep T.;Singh, Deepak [Organic Preparations and Procedures International,2020,p. 1 - 7]