4-[(6,7-DiMethoxy-4-quinolyl)oxy]-2-chloroaniline synthesis

11synthesis methods

Product Name:4-[(6,7-DiMethoxy-4-quinolyl)oxy]-2-chloroaniline
CAS Number:286371-44-6
Molecular formula:C17H15ClN2O3
Molecular Weight:330.77

35654-56-9 Synthesis

35654-56-9
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52671-64-4
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4-[(6,7-DiMethoxy-4-quinolyl)oxy]-2-chloroaniline

286371-44-6
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Yield:286371-44-6 97%

Reaction Conditions:

Stage #1: 4-Amino-3-chlorophenol hydrochloridewith sodium hydride in dimethyl sulfoxide at 20; for 0.166667 h;
Stage #2: 6,7-dimethoxy-4-chloroquinoline in dimethyl sulfoxide at 110; for 12 h;

References:

Kubo, Kazuo;Shimizu, Toshiyuki;Ohyama, Shin-Ichi;Murooka, Hideko;Iwai, Akemi;Nakamura, Kazuhide;Hasegawa, Kazumasa;Kobayashi, Yoshiko;Takahashi, Noriko;Takahashi, Kazumi;Kato, Shinichiro;Izawa, Toshio;Isoe, Toshiyuki [Journal of Medicinal Chemistry,2005,vol. 48,# 5,p. 1359 - 1366]

35654-56-9 Synthesis

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17609-80-2 Synthesis