ChemicalBook CAS DataBase List 4-Amino-3-chlorophenol

4-Amino-3-chlorophenol synthesis

12synthesis methods

Product Name:4-Amino-3-chlorophenol
CAS Number:17609-80-2
Molecular formula:C6H6ClNO
Molecular Weight:143.57

Starting from o-chloronitrobenzene with introducing hydroxyl groups in the presence of strong acids and molybdenum salts as catalysts could synthesize 4-amino-3-chlorophenol. Besides, using m-chlorophenol as a starting material and introducing hydroxyl on a benzene ring through diazotization and coupling also could synthesize 4-Amino-3-chlorophenol.

491-11-2
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$52.00/1g

17609-80-2
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$39.00/5g

Yield:17609-80-2 88%

Reaction Conditions:

with iron;acetic acid at 26 - 80; for 16 h;

Steps:

3-chloro-4-nitrophenol (5.0 g, 28.8 mmol) was added to ethanol (50 ml) at 26 °C and then iron powder (9.6 g,172.9 mmol) and acetic acid (10 mL) were added thereto. The solution was stirred at 80 °C for 16 hours and then cooledto 15 °C. The solution was concentrated and purified by column chromatography to give compound 134A (pale red solid,3.6 g, the yield was 88%).

References:

GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD;LONG, Chaofeng;CHEN, Zhengxia;CHEN, Xiaoxin;ZHANG, Yang;LIU, Zhuowei;LI, Peng;CHEN, Shuhui;LIANG, Guibai;XIE, Cheng;LI, Zhengwei;FU, Zhifei;HU, Guoping;LI, Jian EP3293177, 2018, A1 Location in patent:Paragraph 0342; 0343

FullText

Acetamide, N-[4-(acetyloxy)-2-chlorophenyl]-

60144-85-6
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17609-80-2
303 suppliers
$39.00/5g

References

88-73-3 Synthesis

88-73-3
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$16.00/25g

17609-80-2
303 suppliers
$39.00/5g

95-51-2
373 suppliers
$5.00/5 g

References

88-73-3 Synthesis

88-73-3
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$16.00/25g

17609-80-2
303 suppliers
$39.00/5g

References

123-30-8 Synthesis

123-30-8
605 suppliers
$10.00/5g

17609-80-2
303 suppliers
$39.00/5g

References

4-Amino-3-chlorophenol Related Search:

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