4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE synthesis
- Product Name:4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE
- CAS Number:42754-96-1
- Molecular formula:C5H2Cl2N4
- Molecular Weight:189
2465-59-0
158 suppliers
$29.00/250mg
42754-96-1
219 suppliers
$7.00/100mg
Yield:42754-96-1 87%
Reaction Conditions:
Stage #1:oxypurinol with trichlorophosphate at 20; for 0.25 h;
Stage #2: with triethylamine at 55 - 110; for 5.16667 h;
Steps:
4 4.5. 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine (4)
To 1,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-dione (3) (1.233 mol), phosphorous oxychloride (2.84 mol) was added withstirring at 20 °C. After stirring for 15 min, the mixturewas heated at 55 °C, and triethylamine (2.53 mol) was added over a period of 1 h at a rate that maintains the internal temperature below 65 °C, then mixturewas slowly heated to an internal temperature of 85 °C for 10 min and then heated at 108-110 °C for 4 h to obtain a clear brown-yellow solution. The reaction mixture was cooled to an internal temperature of 40 °C and warm water was added over aperiod of 30-40 min. The solid was collected by filtration to afford pure 4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine (4) as light yellow solid; (5.35 g, 87%); mp: 173-175 °C.
References:
Singla, Prinka;Luxami, Vijay;Singh, Raja;Tandon, Vibha;Paul, Kamaldeep [European Journal of Medicinal Chemistry,2017,vol. 126,p. 24 - 35]
50270-27-4
250 suppliers
$23.00/1g
42754-96-1
219 suppliers
$7.00/100mg
50270-27-4
250 suppliers
$23.00/1g
302-01-2
100 suppliers
$39.89/5g
42754-96-1
219 suppliers
$7.00/100mg