4,6-Dichloro-2-methylpyrimidine synthesis
- Product Name:4,6-Dichloro-2-methylpyrimidine
- CAS Number:1780-26-3
- Molecular formula:C5H4Cl2N2
- Molecular Weight:163
1194-22-5
125 suppliers
$6.00/5g
1780-26-3
471 suppliers
$10.00/10g
Yield:1780-26-3 94%
Reaction Conditions:
with thionyl chloride in acetonitrile at 80; for 3 h;Industrial scale;Temperature;Concentration;Reagent/catalyst;
Steps:
3.1 first step: Synthesis of 4,6-Dichloro-2-methylpyrimidine
4,6-dihydroxy-2-methylpyrimidine (5.0 g, 0.04 mol) was added to a mixed solution of thionyl chloride (18.9 g, 0.16 mol) and acetonitrile,The reaction was stirred at 80 ° C for 3 hours, and the plate was confirmed to disappear. The excess thiophenolate was distilled off under reduced pressure and the residue was poured into 50 g of ice water. The precipitated solid was filtered and purified by column chromatography to give 6.1 g (yield: 94%) of solid.
References:
Shanghai ZaiQi Bio-Tech Co., Ltd,;Wang, Zhiguo;Song, Yanhong;Ma, Xiujuan;Tian, Beibei;Li, Shijiang;Li, Chao;Li, Qiang;Li, Tao CN106478519, 2017, A Location in patent:Paragraph 0020-0023; 0030-0032; 0038-0040; 0049-0052
40497-30-1
326 suppliers
$14.00/5g
1780-26-3
471 suppliers
$10.00/10g