ChemicalBook CAS DataBase List 4,6-Dichloropyrido[3,2-d]pyrimidine

4,6-Dichloropyrido[3,2-d]pyrimidine synthesis

10synthesis methods

Product Name:4,6-Dichloropyrido[3,2-d]pyrimidine
CAS Number:175358-02-8
Molecular formula:C7H3Cl2N3
Molecular Weight:200.02

6-chloropyrido[3,2-d]pyrimidin-4(3H)-one

171178-33-9
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$51.00/100mg

175358-02-8
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$40.00/100mg

Yield: 92.8%

Reaction Conditions:

with thionyl chloride in N,N-dimethyl-formamide at 80; for 2 h;

Steps:

9.1 Step 1
4,6-Dichloropyrido[3,2-d]pyrimidine To a mixture of 6-chloropyrido[3,2-d]- pyrimidin-4(1H)-one (4.5 g, 24.8 mmol, 1 eq) in SOCl₂ (49.20 g, 413.55 mmol, 30 mL, 16.69 eq) was added DMF (90.57 mg, 1.24 mmol, 95.34 uL, 0.05 eq). The mixture was stirred at 80 °C for 2 h. The solvent was evaporated. The residue was dissolved in EtOAc (300 mL), washed with saturated NaHCO3 aqueous solution (100 mL), the organic layer was dried over Na2SO4, and concentrated to afford the title compound (4.6 g, 23.00 mmol, 92.8% yield) as yellow solid which was used directly in the next step without further purification

References:

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;HEYMACH, John;ROBICHAUX, Jacqulyne;NILSSON, Monique;JONES, Philip;CROSS, Jason;THEROFF, Jay WO2020/219904, 2020, A1 Location in patent:Paragraph 0519

171178-33-9
83 suppliers
$51.00/100mg

175358-02-8
85 suppliers
$40.00/100mg

References

37538-67-3 Synthesis

37538-67-3
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$45.00/1g

175358-02-8
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$40.00/100mg

References

4-chloro-5H,6H-pyrido[3,2-d]pyrimidin-6-one

1242446-83-8
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inquiry

175358-02-8
85 suppliers
$40.00/100mg

References

93683-65-9
152 suppliers
inquiry

175358-02-8
85 suppliers
$40.00/100mg

References