![](/CAS/GIF/175358-02-8.gif)
4,6-Dichloropyrido[3,2-d]pyrimidine synthesis
- Product Name:4,6-Dichloropyrido[3,2-d]pyrimidine
- CAS Number:175358-02-8
- Molecular formula:C7H3Cl2N3
- Molecular Weight:200.02
![6-chloropyrido[3,2-d]pyrimidin-4(3H)-one](/CAS/GIF/171178-33-9.gif)
171178-33-9
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$51.00/100mg
![4,6-Dichloropyrido[3,2-d]pyrimidine](/CAS/GIF/175358-02-8.gif)
175358-02-8
85 suppliers
$40.00/100mg
Yield: 92.8%
Reaction Conditions:
with thionyl chloride in N,N-dimethyl-formamide at 80; for 2 h;
Steps:
9.1 Step 1
4,6-Dichloropyrido[3,2-d]pyrimidine To a mixture of 6-chloropyrido[3,2-d]- pyrimidin-4(1H)-one (4.5 g, 24.8 mmol, 1 eq) in SOCl2 (49.20 g, 413.55 mmol, 30 mL, 16.69 eq) was added DMF (90.57 mg, 1.24 mmol, 95.34 uL, 0.05 eq). The mixture was stirred at 80 °C for 2 h. The solvent was evaporated. The residue was dissolved in EtOAc (300 mL), washed with saturated NaHCO3 aqueous solution (100 mL), the organic layer was dried over Na2SO4, and concentrated to afford the title compound (4.6 g, 23.00 mmol, 92.8% yield) as yellow solid which was used directly in the next step without further purification
References:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;HEYMACH, John;ROBICHAUX, Jacqulyne;NILSSON, Monique;JONES, Philip;CROSS, Jason;THEROFF, Jay WO2020/219904, 2020, A1 Location in patent:Paragraph 0519
![6-chloropyrido[3,2-d]pyrimidin-4(3H)-one](/CAS/GIF/171178-33-9.gif)
171178-33-9
83 suppliers
$51.00/100mg
![4,6-Dichloropyrido[3,2-d]pyrimidine](/CAS/GIF/175358-02-8.gif)
175358-02-8
85 suppliers
$40.00/100mg
![Pyrido[3,2-d]pyrimidin-4(1H)-one (9CI)](/CAS/GIF/37538-67-3.gif)
37538-67-3
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$45.00/1g
![4,6-Dichloropyrido[3,2-d]pyrimidine](/CAS/GIF/175358-02-8.gif)
175358-02-8
85 suppliers
$40.00/100mg
![4-chloro-5H,6H-pyrido[3,2-d]pyrimidin-6-one](/CAS/20200401/GIF/1242446-83-8.gif)
1242446-83-8
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![4,6-Dichloropyrido[3,2-d]pyrimidine](/CAS/GIF/175358-02-8.gif)
175358-02-8
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$40.00/100mg
![6-CHLORO-2-CYANO-3-NITROPYRIDINE](/CAS/GIF/93683-65-9.gif)
93683-65-9
152 suppliers
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![4,6-Dichloropyrido[3,2-d]pyrimidine](/CAS/GIF/175358-02-8.gif)
175358-02-8
85 suppliers
$40.00/100mg