4,6-Dihydroxy-5-formylpyrimidine synthesis

Yield: 5.77 g

Reaction Conditions:

with water at 20 - 30; for 18 h;

Steps:

2.3 Synthesis of 4,6-dihydroxypyrimidine-5-carboxaldehyde
Add water (30ml) to the reaction flask and stir.Warm up to 20-30 ° C,Add N-((4,6-dihydroxypyrimidin-5-yl)methylene)-N-methylmethylammonium chloride salt (10.0 g, 49.11 mmol) at 20-30 °C.Reaction at 20-30 ° C for 18 hours,50 ml of absolute ethanol was added to the reaction mixture, stirred, filtered, and the filter cake was washed with a small amount of anhydrous ethanol.Drain,Drying in vacuo at 40-45 ° C gave 5.77 g of a yellow solid.

References:

He Ji Whampoa Pharmaceutical (Shanghai) Co., Ltd.;Liu Bo;Zhang Bin;Yan Huixin;Ge Chongfeng CN108178748, 2018, A Location in patent:Paragraph 0051; 0052; 0063-0065