4-Acetyl-2-methylbenzoic acid amide synthesis
- Product Name:4-Acetyl-2-methylbenzoic acid amide
- CAS Number:1095275-06-1
- Molecular formula:C10H11NO2
- Molecular Weight:177.2
1095275-05-0
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Yield:1095275-06-1 92.5 %
Reaction Conditions:
with ammonium hydroxide at 0 - 8;
Steps:
16
General procedure: Add 50mL of toluene, 0.1mol of 2-methyl-4-acetylbenzoic acid 17.82g, and 1g of DMF into the reaction flask, stir to dissolve, add 15g of thionyl chloride dropwise into the reaction flask, and the dropwise addition is completed in 30 minutes ; After heating up to 60-65°C, react for 5h,After the reaction, at 60-65°C, distill the toluene under reduced pressure until no liquid comes out, then cool down to 0°C, add 3.5g of methanol dropwise into the system, and control the temperature at 0-8°C during the dropping process. Add 50 mL of distilled water for washing, and centrifuge and dry to obtain 18.1 g of a yellow solid with a purity of 99.2% and a yield of 94.2%.
References:
CN115477577,2022,A Location in patent:Paragraph 0064-0065
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