4-ALLYL-5-PHENYL-4H-[1,2,4]TRIAZOLE-3-THIOL synthesis

5synthesis methods

Product Name:4-ALLYL-5-PHENYL-4H-[1,2,4]TRIAZOLE-3-THIOL
CAS Number:23714-53-6
Molecular formula:C11H11N3S
Molecular Weight:217.29

26029-04-9 Synthesis

Benzoic acid, 2-[(2-propen-1-ylaMino)thioxoMethyl]hydrazide

26029-04-9
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4-ALLYL-5-PHENYL-4H-[1,2,4]TRIAZOLE-3-THIOL

23714-53-6
11 suppliers
$57.50/250mg

Yield:23714-53-6 412 mg

Reaction Conditions:

with potassium hydroxide in ethanol;water at 100;

Steps:

4.1.1.2 4.1.1.2. Cyclization

General procedure: The thiosemicarbazide intermediates were solubilized in a mixture of water and ethanol (2:3) and KOH (3 equiv., 3mmol) was added. After refluxing for 2h, the mixture was neutralized with saturated aqueous KHSO₄ and extracted twice with DCM. The organic phases were mixed, dried over MgSO₄, filtered and evaporated under vacuum. The residues were purified by gel column chromatography (EtOAc/Hexane) or by reverse phase HPLC.

References:

Gavara, Laurent;Legru, Alice;Verdirosa, Federica;Sevaille, Laurent;Nauton, Lionel;Corsica, Giuseppina;Mercuri, Paola Sandra;Sannio, Filomena;Feller, Georges;Coulon, Rémi;De Luca, Filomena;Cerboni, Giulia;Tanfoni, Silvia;Chelini, Giulia;Galleni, Moreno;Docquier, Jean-Denis;Hernandez, Jean-Fran?ois [Bioorganic Chemistry,2021,vol. 113,art. no. 105024]

613-94-5 Synthesis