4-Amino-2-ethoxypyridine synthesis
- Product Name:4-Amino-2-ethoxypyridine
- CAS Number:89943-12-4
- Molecular formula:C7H10N2O
- Molecular Weight:138.17
7598-35-8
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89943-12-4
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$25.00/250mg
Yield: 76%
Reaction Conditions:
with sodium hydroxide in ethanol;water
Steps:
19.l f
l) 2-Ethoxy-4-aminopyridine (Den Hertog, Kolder and Combe, 1951) 2-Bromo-4-aminopyridine (4 g). solid sodium hydroxide (4 g) and ethanol (15 ml) were heated in a bomb at 160° C. for 6 hours and allowed to cool. Water was then added and the solvent partially removed under reduced pressure. The mixture was then extracted with ether and the solvent removed, leaving a clear oil of 2-Ethoxy-4-aminopyridine (164 g, 76%) which slowly crystallized into colourless needles, m.p. 88-89° C.
References:
Polychip Pharmaceuticals Pty Ltd;The University of Sydney US5929082, 1999, A
14432-12-3
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64-17-5
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89943-12-4
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14432-12-3
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89943-12-4
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26452-80-2
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89943-12-4
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1124-33-0
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89943-12-4
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$25.00/250mg