ChemicalBook CAS DataBase List 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine synthesis

4synthesis methods

Product Name:3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS Number:151266-23-8
Molecular formula:C5H4IN5
Molecular Weight:261.02

A solution of 3H-pyrazolo[3,4-d]pyrimidin-4-amine (10 g, 0.074 mol) and n-iodo-succinamide (25 g, 0.111 mol) in DMF (80 mL) was heated to 80° C. overnight under an argon atmosphere. The resulting solid was filtered and rinsed with cold EtOH. The product was dried in vacuo overnight to yield 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (24 g, 100 per cent yield).

516-12-1 Synthesis

516-12-1
535 suppliers
$5.00/5g

2380-63-4 Synthesis

2380-63-4
362 suppliers
$9.00/1g

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

151266-23-8
329 suppliers
$22.00/1g

Yield:151266-23-8 86%

Reaction Conditions:

in N,N-dimethyl-formamide at 80; for 12 h;

Steps:

1.1 synthesis of 3-iodo-1H-Pyrazolo[3, 4-d] pyrimidine-4-amine
Pyrazolo [3,4-d] pyrimidin-4-amine (15.0 g, 111.1 mmol) was dissolved in DMF (150 mL) N-iodosuccinimide (37.5 g, 166. 6 mmol) was slowly added to the reaction mixture, and the reaction was stirred at 80 ° C for 12 h. stopWater (40 mL) was added to the reaction mixture, and the mixture was suction filtered. The solid was washed with water (80 mL), ethanol (60 mL) and dried to give to a yellow solid (24. 9 g, 86%).

References:

Guangdong HEC Pharmaceutical Co., Ltd;LIU, BING;BAI, SHUN;ZHANG, YINGJUN;ZHENG, CHANGCHUN;YANG, TIPING;ZHOU, YOUBAI CN105399756, 2016, A Location in patent:Paragraph 0155; 0165-0166

FullText

2380-63-4 Synthesis

2380-63-4
362 suppliers
$9.00/1g

151266-23-8
329 suppliers
$22.00/1g

References

2H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI)

64834-00-0
7 suppliers
inquiry

151266-23-8
329 suppliers
$22.00/1g

References

5399-92-8
232 suppliers
$13.43/250mgs:

151266-23-8
329 suppliers
$22.00/1g

References

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Related Search:

Zidovudine 3-BROMO-4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine 4-Aminopyrazolo[3,4-d]pyrimidine 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine N4-Benzoylcytosine Pyrrolo[2,3-d]pyrimidin-4-ol 4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine 2-Thiouracil 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine