4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid synthesis
- Product Name:4-Amino-5-ethylsulfonyl-2-methoxybenzoic acid
- CAS Number:71675-87-1
- Molecular formula:C10H13NO5S
- Molecular Weight:259.28
1119455-01-4
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71675-87-1
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Yield:71675-87-1 82%
Reaction Conditions:
Stage #1:methyl 4-amino-5-(ethylthio)-2-methoxybenzoate with dihydrogen peroxide;sodium tungstate in isopropyl alcohol at 40 - 45;Industry scale;
Stage #2: with water;sodium hydroxide in isopropyl alcohol at 60 - 65;Industry scale;
Stage #3: with hydrogenchloride in water;isopropyl alcohol; pH=4 - 4.5Industry scale;
Steps:
6
30% Hydrogen peroxide was slowly added to a solution of the 4-amino-2-methoxy-5- ethylthio methyl benzoate (X) (1.21 Kg) in isopropyl alcohol (4.84 Lit.) containing sodium tungstate (0.0082 Kg) as a catalytic amount at ambient temperature. The mixture was stirred at 40-45°C for 3-4 hrs then cooled to 5-10°C. 5% sodium thiosulphate solution (0.06 Kg in 18.15 lit. water) was added to reaction mixture. Reaction mass was stirred for 60 min and 2- methoxy-4-amino-5-ethyl-sulfonyl methyl benzoate (XI) was obtained in situ. To the reaction mixture was added sodium hydroxide (1.00 Kg, in 10 lit. water). The temperature was raised up to 60-65 °C and stirred the reaction mixture for 2-3 hrs. The reaction mass was cooled and adjusted pH 4.0 - 4.5 by using diluted hydrochloric acid (1 : 10). The product was isolated by filtration under suction.Yield : 82%Purity: 99%
References:
LUPIN LIMITED;PAGHDAR, Dinesh, Jayntibhai;KOLEKAR, Mahesh, Ramkumar;DESHPANDE, Tushar, Nandkumar;PATIL, Suryaprakash, Pandurang;CHAVAN, Yuvraj, Atmaram;RAY, Purna, Chandra;SINGH, Girij, Pal WO2011/158084, 2011, A1 Location in patent:Page/Page column 12
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71675-87-1
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71675-87-1
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