ChemicalBook CAS DataBase List 4-(Aminomethyl)benzonitrile hydrochloride

4-(Aminomethyl)benzonitrile hydrochloride synthesis

7synthesis methods

Product Name:4-(Aminomethyl)benzonitrile hydrochloride
CAS Number:15996-76-6
Molecular formula:C8H9ClN2
Molecular Weight:168.62

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4-(Aminomethyl)benzonitrile hydrochloride

15996-76-6
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Yield:15996-76-6 99%

Reaction Conditions:

with hydrogenchloride in ethyl acetate

Steps:

1 EXAMPLE 1
In a 200 ml four-neck flask equipped with an agitator, a thermometer, a gas conduit, and a reflux condenser, p-cyanobenzylamine (10.0 g) obtained in Preparation Example 3 was dissolved in ethyl acetate (90.0 g). While the reactor was cooled in a water bath, hydrogen chloride gas was fed into the vapor phase of the reactor while stirring. Immediately after the introduction of hydrogen chloride, heat generation was confirmed, and a white solid was precipitated. After the reaction mixture was cooled to room temperature, the white solid was separated through filtration and dried in a desiccator under vacuum, thereby yielding 12.6 g of p-cyanobenzylamine hydrochloride (yield based on p-cyanobenzylamine: 99%). Through high-performance liquid chromatographic analysis of the thus-obtained p-cyanobenzylamine hydrochloride, the p-cyanobenzylamine content in the hydrochloride was found to be 77 mass %. In addition, the hydrogen chloride content in p-cyanobenzylamine hydrochloride was found to be 23 mass % through anion chromatographic analysis. The thus-obtained p-cyanobenzylamine hydrochloride has a bulk density of 0.3 g/ml.

References:

Showa Denko K.K. US6392083, 2002, B1 Location in patent:Page column 6

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