ChemicalBook CAS DataBase List 4-(Aminomethyl)piperidine

4-(Aminomethyl)piperidine synthesis

4synthesis methods

Product Name:4-(Aminomethyl)piperidine
CAS Number:7144-05-0
Molecular formula:C6H14N2
Molecular Weight:114.19

4395-98-6 Synthesis

4395-98-6
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$14.00/1g

7144-05-0
213 suppliers
$6.00/1g

Yield:7144-05-0 92%

Reaction Conditions:

with hydrogen in ethanol at 88; under 45004.5 Torr; for 1 h;

Steps:

5
In the 1L hydrogenation kettle, add 100 g of 4-piperidine carbonitrile and 3 g of Raney-Ni, 400 mL of ethanol, and continuously charged with H2, so that the pressure of the system during the reaction was always maintained at 6 MPa. After reaction at a reaction temperature of 88 ° C for 1 h, then the temperature was lowered. When the temperature in the reaction vessel was lowered to room temperature, the gas was vented, and 4-piperidine methyl amine (purity: 99% or more) was obtained by filtration and recrystallization in a yield of 92 wt%.

References:

Sinopec Corporation;Sinopec Yangzi Petrochemical Co., Ltd.;Sun Hailong;Wei Yanyu;Gao Yilong;Chen Xinhua;Miao Jun;Li Na;Kan Lin;Bai Jiye;Chen Shaohui;Yang Aiwu;Xu Yuexing CN104557356, 2017, B Location in patent:Paragraph 0240

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