Isonipecotamide synthesis
- Product Name:Isonipecotamide
- CAS Number:39546-32-2
- Molecular formula:C6H12N2O
- Molecular Weight:128.17
2971-79-1
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39546-32-2
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Yield:-
Reaction Conditions:
with ammonia;potassium carbonate in methanol at 140 - 150;
Steps:
Step B: piperidine-4-carboxamide
To a mixture of methyl piperidine-4-carboxylate (590g, 3.10mol) in NH3/MeOH (4.5L, V/V 40) was added K2CO3 (5.0g, 36mmol) . The resulting reaction mixture was heated to 140-150 overnight. The next day the solvent was removed on the rotary evaporator, and the crude product recrystallized by CH3OH/EtOAc to afford the title compound.
References:
WO2016/65582,2016,A1 Location in patent:Page/Page column 49
1453-82-3
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91419-48-6
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