![](/CAS/GIF/38041-19-9.gif)
4-Aminotetrahydropyran synthesis
- Product Name:4-Aminotetrahydropyran
- CAS Number:38041-19-9
- Molecular formula:C5H11NO
- Molecular Weight:101.15
4-Aminotetrahydropyran can be synthesized from 4-cyanotetrahydropyran and sodium hydroxide solution as raw materials to synthesize 4-formamide tetrahydropyran, and then slowly add sodium hypochlorite solution to 4-formamide tetrahydropyran. Synthesized by decarboxylation.
![Tetrahydro-4H-pyran-4-one](/CAS/GIF/29943-42-8.gif)
29943-42-8
420 suppliers
$5.00/1g
![4-Aminotetrahydropyran](/CAS/GIF/38041-19-9.gif)
38041-19-9
315 suppliers
$6.00/1g
Yield:38041-19-9 90 %Chromat.
Reaction Conditions:
with ammonium hydroxide;nickel-aluminum alloy;water at 20; for 2 h;Sonication;Green chemistry;
Steps:
Reductive Amination of Ketones in NH4OH; Cyclohexylamine; Typical Procedure
General procedure: Ni-Al alloy (200 mg) and cyclohexanone (35 μL, 0.34 mmol) were suspended in 28-30% NH4OH (3 mL) and sonicated (Branson 1510MTH ultrasonic bath) for 2 h. After the completion of the reaction, the excess alloy and solid by-products were removed by filtration. The filtrate was extracted with EtOAc (2 × 2 mL). The organic extracts were combined and dried over anhyd Na2SO4. The solvent was removed in vacuo and the crude product was purified by flash chromatography.
References:
Schäfer, Christian;Niśanci, Bilal;Bere, Matthew P.;Daśtan, Arif;Török, Béla [Synthesis,2016,vol. 48,# 18,art. no. SS-2016-M0224-OP,p. 3127 - 3133]
![TETRAHYDRO-PYRAN-4-ONE OXIME](/CAS/GIF/61128-73-2.gif)
61128-73-2
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$38.00/1g
![4-Aminotetrahydropyran](/CAS/GIF/38041-19-9.gif)
38041-19-9
315 suppliers
$6.00/1g
![TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE](/CAS/GIF/344329-76-6.gif)
344329-76-6
116 suppliers
$7.00/250mg
![4-Aminotetrahydropyran](/CAS/GIF/38041-19-9.gif)
38041-19-9
315 suppliers
$6.00/1g
![N-BENZHYDRYL-TETRAHYDRO-2H-PYRAN-4-AMINE](/CAS/GIF/625126-73-0.gif)
625126-73-0
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![4-Aminotetrahydropyran](/CAS/GIF/38041-19-9.gif)
38041-19-9
315 suppliers
$6.00/1g
![Tetrahydro-4-pyranol](/CAS/GIF/2081-44-9.gif)
2081-44-9
285 suppliers
$6.00/1g
![4-Aminotetrahydropyran](/CAS/GIF/38041-19-9.gif)
38041-19-9
315 suppliers
$6.00/1g