ChemicalBook CAS DataBase List 4-Benzothiazolol, 2-methyl

4-Benzothiazolol, 2-methyl synthesis

5synthesis methods

Product Name:4-Benzothiazolol, 2-methyl
CAS Number:94977-59-0
Molecular formula:C8H7NOS
Molecular Weight:165.21

5304-19-8 Synthesis

Benzothiazole, 4-methoxy-2-methyl- (7CI,8CI,9CI)

5304-19-8
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94977-59-0
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Yield:94977-59-0 75%

Reaction Conditions:

with pyridine hydrochloride at 150; for 1 h;

Steps:

E E. 2-Methylbenzo[d]thiazol-4-ol

A mixture of 4-methoxy-2-methylbenzo[d]thiazole (Intermediate 133D) (4.00 g, 16.4 mmol) and pyridine hydrochloride (18.90 g, 164 mmol) was heated to 150 °C. After 1 h, the reaction was cooled and diluted with ice water (100 mL) and extracted with EtOAc (2 X 150 mL). The combined organic layers were washed with brine, dried over Na₂S0₄, filtered and concentrated to give the title compound (3.00 g, 75%) as a yellow solid. ¹H NMR (400 MHz, CDCI₃) δ 2.81 (s, 3 H), 6.94-6.98 (m, 1 H), 7.23-7.28 (m, 1 H), 7.31 -7.36 (m, 1 H); LC-MS (LC- ES) M+H = 166.

References:

WO2018/69863,2018,A1 Location in patent:Page/Page column 249-250