ChemicalBook CAS DataBase List 4-Benzyloxybromobenzene

4-Benzyloxybromobenzene synthesis

13synthesis methods

Product Name:4-Benzyloxybromobenzene
CAS Number:6793-92-6
Molecular formula:C13H11BrO
Molecular Weight:263.13

106-41-2
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100-39-0
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6793-92-6
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Yield: 100%

Reaction Conditions:

with potassium carbonate in acetonitrile for 6 h;

Steps:

34.A
Intermediate 34; (+/-)-3-(4-Hydroxy-phenyl)-2-methyl-propionic acid methyl ester; Step A; 4-Bromophenol (3.55 g, 20.5 mmol) is dissolved in acetonitrile (50 mL). Powdered potassium carbonate (3.86 g, 27.9 mmol) is added while stirring, followed by dropwise addition of benzyl bromide (2.4 mL, 20.2 mmol). The mixture is vigorously stirred under nitrogen for 6 h. Filtration and concentration yielded 4-benzyloxy-bromobenzene 32 (5.52 g, quant.) as an oil that slowly solidified: ¹H-NMR (400 MHz, CDCl₃) δ = 7.37, (m, 7H), 6.87 (m, 2H), 5.07 (s, 2H).

References:

IRM LLC WO2007/56497, 2007, A1 Location in patent:Page/Page column 32

106-41-2
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$13.00/5g

100-44-7 Synthesis