ChemicalBook CAS DataBase List 3-BENZYLOXYBROMOBENZENE

3-BENZYLOXYBROMOBENZENE synthesis

5synthesis methods

Product Name:3-BENZYLOXYBROMOBENZENE
CAS Number:53087-13-1
Molecular formula:C13H11BrO
Molecular Weight:263.13

591-20-8
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100-39-0
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53087-13-1
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Yield:53087-13-1 100%

Reaction Conditions:

with potassium carbonate in acetone; for 15 h;Reflux;

Steps:

79.79-1 Preparation of 1-(benzyloxy)-3-bromobenzene

A solution of 3-bromophenol (3 g, 17.34 mmol) in acetone (100 mL) was added with benzyl bromide (2.2 mL, 19.07 mmol) and K₂CO₃ (7.0 g, 52.02 mmol), and the resulting mixture was refluxed for 15 hours. The reaction mixture was cooled to room temperature, filtered, and washed with acetone. The filtrate was concentrated and purified by silica gel chromatography to obtain the title compound (white solid, 5.1 g, 100% yield). ¹H NMR (300 MHz, CDCl₃) δ 7.50 - 7.30 (m, 5H), 7.20 - 7.01 (m, 3H), 6.98 - 6.80 (m, 1H), 5.05 (s, 2H).

References:

EP2963027,2016,A1 Location in patent:Paragraph 1227; 1228; 1229

591-20-8
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$10.00/1g

100-44-7 Synthesis