4-BROMO-1-METHYL-1H-INDOLE synthesis
- Product Name:4-BROMO-1-METHYL-1H-INDOLE
- CAS Number:590417-55-3
- Molecular formula:C9H8BrN
- Molecular Weight:210.07
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Yield: 91%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 140;
Steps:
4.2.10 4-Bromo-3-acetyl-1-methyl-1H-indole (32)
A suspension of 31 (8.8g, 45mmol), potassium carbonate (4.5g, 32mmol), and dimethyl carbonate (12g, 0.13mol) in DMF (56mL) was gradually heated to 140°C over 30min and stirred for 3.5h. After cooling to room temperature, the insoluble solids were removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was distilled under reduced pressure (0.2mmHg, 155-180°C) to give 8.5g (91%) of 4-bromo-1-methylindole as a yellow liquid. Its 1H NMR spectroscopic data were consistent with those reported in the literature.48
References:
Fu, Tsung-Hao;McElroy, William T.;Shamszad, Mariam;Heidebrecht Jr., Richard W.;Gulledge, Brian;Martin, Stephen F. [Tetrahedron,2013,vol. 69,# 27-28,p. 5588 - 5603]
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590417-55-3
80 suppliers
$48.10/250mg
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590417-55-3
80 suppliers
$48.10/250mg
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$15.00/1g
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590417-55-3
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$48.10/250mg
74-88-4
351 suppliers
$15.00/10g
590417-55-3
80 suppliers
$48.10/250mg