![](/CAS/GIF/486460-26-8.gif)
(4-bromo-2,5-difluorophenyl)methanol synthesis
- Product Name:(4-bromo-2,5-difluorophenyl)methanol
- CAS Number:486460-26-8
- Molecular formula:C7H5BrF2O
- Molecular Weight:223.01
![4-bromo-2,5-difluorobenzaldehyde](/CAS/GIF/357405-75-5.gif)
357405-75-5
117 suppliers
$12.00/250mg
![(4-bromo-2,5-difluorophenyl)methanol](/CAS/GIF/486460-26-8.gif)
486460-26-8
58 suppliers
$110.00/100mg
Yield:486460-26-8 94.47%
Reaction Conditions:
with sodium tetrahydroborate in methanol at 80; for 0.5 h;
Steps:
1 Synthesis of BDl
NaBH4 (128.38 mg, 3.39 mmol) was added to a solution of 150.00 g Compound BD1- 1 (i.e., 4-bromo-2,5-difluorobenzaldehyde) in MeOH (4.00 mL). The mixture was stirred at 80°C for 30 minutes. TLC indicated Compound BDl-l was consumed completely in this reaction time. An additional compound with a larger polarity than Compound BDl-l was measured. The reaction mixture was concentrated to remove MeOH, then diluted with saturated NaHC03 (4 ml), extracted with DCM (5 mL * 3), the combined organic layer was washed with saturated brine (5 mL * 2), dried over Na2S04, filtered and concentrated to give a residue. The residue was purified by prep-TLC (S1O2, Petroleum ether:Ethyl acetate mixture with a ratio of 3: 1) to afford Compound BDl-2 (143.00 mg, 641.23 τηο, 94.47% yield) as a white solid.
References:
WO2018/75871,2018,A1 Location in patent:Page/Page column 60
![4-bromo-2,5-difluorobenzoic acid](/CAS/GIF/28314-82-1.gif)
28314-82-1
142 suppliers
$6.00/250mg
![(4-bromo-2,5-difluorophenyl)methanol](/CAS/GIF/486460-26-8.gif)
486460-26-8
58 suppliers
$110.00/100mg
![1,4-Dibromo-2,5-difluorobenzene](/CAS/GIF/327-51-5.gif)
327-51-5
277 suppliers
$5.00/5g
![(4-bromo-2,5-difluorophenyl)methanol](/CAS/GIF/486460-26-8.gif)
486460-26-8
58 suppliers
$110.00/100mg