4-Bromo-2-ethoxybenzoic acid synthesis
- Product Name:4-Bromo-2-ethoxybenzoic acid
- CAS Number:89407-43-2
- Molecular formula:C9H9BrO3
- Molecular Weight:245.07
939983-36-5
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89407-43-2
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Yield:89407-43-2 99%
Reaction Conditions:
with water;sodium hydroxide in tetrahydrofuran at 20; for 2 h;
Steps:
4.2 Step 2: 4-bromo-2-ethoxybenzoic acid
Step 2: 4-bromo-2-ethoxybenzoic acid To a solution containing ethyl 4-bromo-2-ethoxybenzoate (54.7g, 200 mmol) in THF (668 mL) was added 6M NaOH (100 mL, 601 mmol). The resulting mixture was stirred for 2 h at RT and was then concentrated to an aqueous slurry. The concentrate was diluted with more water, and 6M HCI (100 mL, 601 mmol) was added. The mixture was stirred for 5 min and was then filtered washing with water to afford the title compound as a colorless solid. (49.3 g, 99 % yield). MS (m/z) 244.8 (M+H)+
References:
WO2017/6296,2017,A1 Location in patent:Page/Page column 110
1666-28-0
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89407-43-2
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89407-43-2
17 suppliers
$237.00/1g