![](/CAS2/GIF/89407-43-2.gif)
4-Bromo-2-ethoxybenzoic acid synthesis
- Product Name:4-Bromo-2-ethoxybenzoic acid
- CAS Number:89407-43-2
- Molecular formula:C9H9BrO3
- Molecular Weight:245.07
![Benzoic acid, 4-bromo-2-ethoxy-, ethyl ester](/CAS/20210111/GIF/939983-36-5.gif)
939983-36-5
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![4-Bromo-2-ethoxybenzoic acid](/CAS2/GIF/89407-43-2.gif)
89407-43-2
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$237.00/1g
Yield:89407-43-2 99%
Reaction Conditions:
with water;sodium hydroxide in tetrahydrofuran at 20; for 2 h;
Steps:
4.2 Step 2: 4-bromo-2-ethoxybenzoic acid
Step 2: 4-bromo-2-ethoxybenzoic acid To a solution containing ethyl 4-bromo-2-ethoxybenzoate (54.7g, 200 mmol) in THF (668 mL) was added 6M NaOH (100 mL, 601 mmol). The resulting mixture was stirred for 2 h at RT and was then concentrated to an aqueous slurry. The concentrate was diluted with more water, and 6M HCI (100 mL, 601 mmol) was added. The mixture was stirred for 5 min and was then filtered washing with water to afford the title compound as a colorless solid. (49.3 g, 99 % yield). MS (m/z) 244.8 (M+H)+
References:
WO2017/6296,2017,A1 Location in patent:Page/Page column 110
![4-Bromo-2-hydroxybenzoic acid](/CAS/GIF/1666-28-0.gif)
1666-28-0
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![4-Bromo-2-ethoxybenzoic acid](/CAS2/GIF/89407-43-2.gif)
89407-43-2
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$237.00/1g
![METHYL 4-BROMO-2-HYDROXYBENZOATE](/CAS/GIF/22717-56-2.gif)
22717-56-2
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![4-Bromo-2-ethoxybenzoic acid](/CAS2/GIF/89407-43-2.gif)
89407-43-2
17 suppliers
$237.00/1g