4-Bromo-2-hydroxybenzoic acid
- CAS No.
- 1666-28-0
- Chemical Name:
- 4-Bromo-2-hydroxybenzoic acid
- Synonyms
- NSC 109120;4-BROMOSALICYLIC ACID;4-Bromosalicyclic acid;4-Bromosalicylic acid, >=98%;2-Hydroxy-4-bromobenzoicacid;4-bromo-2-hydoxybenzoic acid;4-BROMO-2-HYDROXYBENZOIC ACID;VLOOKUP(C4,[1]Export!$D:$H,5,0);Benzoicacid, 4-bromo-2-hydroxy-;4-Bromo-2-hydroxybenzoic acid 98%
- CBNumber:
- CB4196824
- Molecular Formula:
- C7H5BrO3
- Molecular Weight:
- 217.02
- MDL Number:
- MFCD06797970
- MOL File:
- 1666-28-0.mol
- MSDS File:
- SDS
Melting point | 164-165°C |
---|---|
Boiling point | 330.2±32.0 °C(Predicted) |
Density | 1.861±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
pka | 2.71±0.10(Predicted) |
form | powder |
color | Orange |
InChI | InChI=1S/C7H5BrO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,(H,10,11) |
InChIKey | FYAKLZKQJDBBKW-UHFFFAOYSA-N |
SMILES | C(O)(=O)C1=CC=C(Br)C=C1O |
CAS DataBase Reference | 1666-28-0(CAS DataBase Reference) |
4-Bromo-2-hydroxybenzoic acid price More Price(24)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 716421 | 4-Bromo-2-hydroxybenzoic acid 97% | 1666-28-0 | 5g | $147 | 2024-03-01 | Buy |
TRC | B696148 | 4-Bromo-2-hydroxybenzoic acid | 1666-28-0 | 1g | $75 | 2021-12-16 | Buy |
Biosynth Carbosynth | FB70486 | 4-Bromo-2-hydroxybenzoic acid | 1666-28-0 | 50g | $87.5 | 2021-12-16 | Buy |
AK Scientific | R020 | 4-Bromo-2-hydroxybenzoic acid | 1666-28-0 | 25g | $94 | 2021-12-16 | Buy |
Biosynth Carbosynth | FB70486 | 4-Bromo-2-hydroxybenzoic acid | 1666-28-0 | 25g | $50 | 2021-12-16 | Buy |
4-Bromo-2-hydroxybenzoic acid Chemical Properties,Uses,Production
Chemical Properties
4-Bromo-2-hydroxybenzoic acid is a solid at normal temperature and pressure. It is stable at normal temperature and decomposes into phenol and carbon dioxide after rapid heating. It has some acidic properties.
Uses
2-Hydroxy-4-bromobenzoic acid is used as an anti-scorch agent in drug molecules and rubber industry, as well as an intermediate in the production of ultraviolet absorbers and foaming agents.
Synthesis
Under nitrogen atmosphere, add copper (II) bromide (8.8 g, 39.4 mmol, 1.2 equivalents), acetonitrile (50 ml), and 4-aminosalicylic acid (5.1 g, 49.5 mmol) to the vacuum-dried reaction flask, 1.5 equivalent). The reaction mixture was cooled to 0°C, and 2-hydroxy-4-bromobenzoic acid precursor (5.0 g, 32.6 mmol, 1.0 equiv) was added portion-wise. Additional acetonitrile (25 mL) was added to the mixture and stirred at 0 °C for 2 h. The organic extracts were combined and washed with 20% aqueous hydrochloric acid, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was dissolved in diethyl ether, and the resulting solution was extracted with 15% sodium hydroxide aqueous solution. The aqueous solution was washed with diethyl ether, acidified to pH 1 with 6N hydrochloric acid aqueous solution, and the mixture was extracted with diethyl ether. The combined organic extracts were washed with brine, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was treated with chloroform, and the precipitate collected by filtration was 4-Bromo-2-hydroxybenzoic acid.
4-Bromo-2-hydroxybenzoic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19343 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10828 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
View Lastest Price from 4-Bromo-2-hydroxybenzoic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2023-03-21 | 4-Bromo-2-hydroxybenzoic acid
1666-28-0
|
US $0.00-0.00 / kg T | 1kg T | 99.9%MIN | 20TONS | Milestone Chemical Wuxi Co.,Ltd | ||
2022-10-15 | 4-Bromo-2-hydroxybenzoic acid
1666-28-0
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
2021-07-02 | 4-Bromo-2-hydroxybenzoic acid
1666-28-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
- 4-Bromo-2-hydroxybenzoic acid
1666-28-0
- US $0.00-0.00 / kg T
- 99.9%MIN
- Milestone Chemical Wuxi Co.,Ltd
- 4-Bromo-2-hydroxybenzoic acid
1666-28-0
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
- 4-Bromo-2-hydroxybenzoic acid
1666-28-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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