4-Bromo-2-fluorophenol synthesis
- Product Name:4-Bromo-2-fluorophenol
- CAS Number:2105-94-4
- Molecular formula:C6H4BrFO
- Molecular Weight:191
367-12-4
421 suppliers
$5.00/10g
2105-94-4
345 suppliers
$6.00/5g
Yield:2105-94-4 90%
Reaction Conditions:
with bromine in dichloromethane;water
Steps:
5 Preparation of 2-[4-(4-bromo-2-fluorophenoxy)phenoxy]propionic acid methyl ester STR29
EXAMPLE 5 Preparation of 2-[4-(4-bromo-2-fluorophenoxy)phenoxy]propionic acid methyl ester STR29 To a stirred solution of 2-fluorophenol (22.4 g, 0.2 mol) in methylene chloride (250 ml) which was cooled to ~3° C. in an ice bath, was added, all at once, bromine (31.97 g, 0.2 mol). The resulting solution was stirred at ice bath temperature for two hours and then at room temperature for 1 hour. The mixture was poured into water (600 ml) containing excess sodium bisulfite. The organic phase was separated and the aqueous phase was washed with additional methylene chloride (200 ml). The combined organic extracts were washed with saturated sodium bicarbonate, dried (MgSO4) and the solvent evaporated to give the desired 2-fluoro-4-bromophenol as a colorless oil (34.5 g, 90%). The NMR (CDCl3) was consistent with the assigned structure.
References:
The Dow Chemical Company US4642338, 1987, A
106-41-2
482 suppliers
$13.00/5g
2105-94-4
345 suppliers
$6.00/5g
2357-52-0
307 suppliers
$6.00/5g
2105-94-4
345 suppliers
$6.00/5g
367-12-4
421 suppliers
$5.00/10g
2105-94-4
345 suppliers
$6.00/5g
576-86-3
114 suppliers
$21.00/5g
2040-89-3
166 suppliers
$6.00/1g