![](/CAS/GIF/22282-99-1.gif)
4-Bromo-2-methylpyridine synthesis
- Product Name:4-Bromo-2-methylpyridine
- CAS Number:22282-99-1
- Molecular formula:C6H6BrN
- Molecular Weight:172.02
![4-Amino-2-picoline](/CAS/GIF/18437-58-6.gif)
18437-58-6
314 suppliers
$6.00/1g
![4-Bromo-2-methylpyridine](/CAS/GIF/22282-99-1.gif)
22282-99-1
388 suppliers
$6.00/5g
Yield:22282-99-1 95%
Reaction Conditions:
with hydrogen bromide;bromine at -5;
Steps:
1.3 (3) Preparation of 2-methyl-4-bromopyridine:
2-Methyl-4-aminopyridine (10.8 g, 0.1 mol) was added to 48% HBr (46 ml, 0.4 mol) with ice-cooling.After the addition is completed, the mixture is cooled to -5 ° C, and liquid bromine (15 ml, 0.3 mol) is slowly added dropwise, and the addition is completed in 30-35 minutes.Then, 42% of a 40% sodium nitrite solution was added dropwise at 0 ° C or less, and the addition was completed in 1-1.1 h.After the addition is completed, the mixture is stirred at 0 ° C for 30 min, and then slowly added with 50% sodium hydroxide solution below 20 ° C to adjust the pH of the solution to 9,The reaction solution was extracted with ethyl acetate, dried over anhydrous sodium sulfate grassroots, suction filtered, and concentrated2-Methyl-4-bromopyridine was obtained in a molar yield of 95%.
References:
Danyang Ning David Fang To Detect Co., Ltd.;Wei Qian CN109748854, 2019, A Location in patent:Paragraph 0018; 0021
![2,4-Dibromopyridine](/CAS/GIF/58530-53-3.gif)
58530-53-3
296 suppliers
$4.00/1g
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
340 suppliers
$15.00/10g
![4-Bromo-2-methylpyridine](/CAS/GIF/22282-99-1.gif)
22282-99-1
388 suppliers
$6.00/5g
![Methylmagnesium chloride](/CAS/GIF/676-58-4.gif)
676-58-4
277 suppliers
$15.00/25ml
![4-Bromopyridine hydrochloride](/CAS/GIF/19524-06-2.gif)
19524-06-2
462 suppliers
$6.00/5g
![4-Bromo-2-methylpyridine](/CAS/GIF/22282-99-1.gif)
22282-99-1
388 suppliers
$6.00/5g
![Methylmagnesium Bromide](/CAS/GIF/75-16-1.gif)
75-16-1
263 suppliers
$12.00/10ml
![4-Bromopyridine hydrochloride](/CAS/GIF/19524-06-2.gif)
19524-06-2
462 suppliers
$6.00/5g
![4-Bromo-2-methylpyridine](/CAS/GIF/22282-99-1.gif)
22282-99-1
388 suppliers
$6.00/5g
![4-BROMOPYRIDINE-2-CARBALDEHYDE](/CAS/GIF/131747-63-2.gif)
131747-63-2
164 suppliers
$25.00/250mg
![4-Bromo-2-methylpyridine](/CAS/GIF/22282-99-1.gif)
22282-99-1
388 suppliers
$6.00/5g