(4-BROMO-2-THIENYL)METHANOL synthesis
- Product Name:(4-BROMO-2-THIENYL)METHANOL
- CAS Number:79757-77-0
- Molecular formula:C5H5BrOS
- Molecular Weight:193.06
18791-75-8
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Yield:79757-77-0 96%
Reaction Conditions:
with sodium borohydrid in ethanol;water
Steps:
R.5 [Preparation of 4-Bromothiophene-2-Ylacetonitrile]
Referential Example 5 [Preparation of 4-Bromothiophene-2-Ylacetonitrile] To a solution of 4-bromothiophene-2-carboxaldehyde (9.55 g, 50 mmol, purchased from Aldrich) in 100 ml of ethanol was added sodium borohydride (3.78 g, 100 mmol purchased from Yoneyama Yakuhin) gradually under cooling in an ice bath. After the completion of addition, the mixture was stirred further for 1.5 hours at room temperature. The reaction mixture was acidified with hydrochlorid acid, then was concentrated to dryness under reduced pressure. To the residue was added water and extracted with ether to give 9.29 g (yield: 96%) of 4-bromothiophen-2-ylmethanol as an oil.
References:
Morinaga Milk Industry Co., Ltd. US5589506, 1996, A
18791-75-8
274 suppliers
$9.00/5g
79757-77-0
101 suppliers
$6.00/1g