ChemicalBook CAS DataBase List 4-Bromo-4'-iodobiphenyl

4-Bromo-4'-iodobiphenyl synthesis

7synthesis methods

Product Name:4-Bromo-4'-iodobiphenyl
CAS Number:105946-82-5
Molecular formula:C12H8BrI
Molecular Weight:359

92-66-0 Synthesis

92-66-0
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105946-82-5
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Yield:105946-82-5 93%

Reaction Conditions:

with periodic acid dihydrate;sulfuric acid;iodine;acetic acid at 65 - 90; for 6.5 h;Inert atmosphere;

Steps:

synthesis of intermediate 1-4 (intermediate 1-4)

Under argon atmosphere, were weighed 4-bromo-biphenyl 47. 0g (201. 6mmol), iodine 23. 0g (90. 6mmol), periodic acid dihydrate 9. 4g (41. 2mmol), water was added 42ml, 360ml acetic acid, 11 ml of sulfuric acid, 65 ° C with stirring for 30 minutes, to 90 ° C and further stirred for 6 hours.After the reaction, the reaction mixture after injected into to the ice water, filtered. After washing with water, further washed with methanol, thereby obtaining 67.0g white solid (yield 93%).

References:

CN105431417,2016,A Location in patent:Paragraph 0214; 0215; 0216; 0217