4-Bromo-N,N-dihexylaniline synthesis

5synthesis methods

Product Name:4-Bromo-N,N-dihexylaniline
CAS Number:425604-49-5
Molecular formula:C18H30BrN
Molecular Weight:340.34

4430-09-5 Synthesis

4430-09-5
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425604-49-5
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Yield:425604-49-5 86 %

Reaction Conditions:

with N-Bromosuccinimide in N,N-dimethyl-formamide;Cooling with ice;Darkness;

Steps:

2.iv Step iv, synthesis compound 7:

In the flask, add compound 6 (4.6 g, 17.7 mmol), DMF 20 mL, ice bath, N-bromosuccinimide (NBS, 3.1 g, 17.7 mmol) was dissolved in DMF, added to the flask, and reacted in the dark for 2 days. Add water, extract three times with n-hexane, wash three times with water, dry the organic layer with anhydrous Na2SO4, filter, add silica gel, remove the solvent by rotary evaporation, pass through the column with n-hexane:dichloromethane (volume ratio 5:1) to obtain an oily product Compound 7 (5.2 g, 86%)

References:

CN115108941,2022,A Location in patent:Paragraph 0104; 0114-0119