4-bromo-N1-phenylbenzene-1,2-diamine synthesis

5synthesis methods

Product Name:4-bromo-N1-phenylbenzene-1,2-diamine
CAS Number:68765-53-7
Molecular formula:C12H11BrN2
Molecular Weight:263.13

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Yield:68765-53-7 85%

Reaction Conditions:

with tin(II) chloride dihdyrate in ethanol;ethyl acetate at 90; for 5 h;

Steps:

compound 6 (14.3 g, 48.8 mmol),Tin (II) chloride dehydrate (55.0 g, 244.0 mmol),Ethanol (ethanol, 170 ml), ethyl acetate (ethyl acetate, 170 ml) was used as a solvent, refluxed at 90 ° C for 5 hours, cooled to room temperature, and added with potassium hydroxide aqueous solution to separate layers.It was extracted with ethyl acetate, and dried by a cyclone concentrator to obtain 10.8 g of a pale pink solid.The yield was 85%.

References:

CN109516980,2019,A Location in patent:Paragraph 0036

364-73-8 Synthesis