ChemicalBook CAS DataBase List 4-(bromomethyl)-4'-(trifluoromethyl)-1,1'-biphenyl

4-(bromomethyl)-4'-(trifluoromethyl)-1,1'-biphenyl synthesis

5synthesis methods

Product Name:4-(bromomethyl)-4'-(trifluoromethyl)-1,1'-biphenyl
CAS Number:613241-14-8
Molecular formula:C14H10BrF3
Molecular Weight:315.13

(4'-TRIFLUOROMETHYLBIPHENYL-4-YL)-METHANOL

457889-46-2
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4-(bromomethyl)-4'-(trifluoromethyl)-1,1'-biphenyl

613241-14-8
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Yield:613241-14-8 65%

Reaction Conditions:

with phosphorus tribromide in diethyl ether;dichloromethane at 0; for 2 h;

Steps:

107.B

Step B. 4'-Bromomethyl-4-trifluoromethyl-biphenyl; Phosphorous tribromide (8.67mmol, 1.OM in dichloromethane) is added to a stirred solution of 4'-trifluoromethyl-biphenyl-4-yl)-methanol (2.08g, 8.25mmol) in ethyl ether (40mL) at 0° C under inert atmosphere of nitrogen. The reaction is stirred at 0° C for two hours, quenched at 0° C with water, diluted mixture with ethyl acetate, washed with water, then brine. Organics are dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue is purified by column (silica gel) in 0-40% ethyl acetate/hexane gradient to give 1.68g (5.33mmol, 65%) of title compound.

References:

WO2005/118542,2005,A1 Location in patent:Page/Page column 119

97067-18-0 Synthesis