4-chloro-2, 5-diMethylphenylsulfonyl chloride synthesis
- Product Name:4-chloro-2, 5-diMethylphenylsulfonyl chloride
- CAS Number:145980-63-8
- Molecular formula:C8H8Cl2O2S
- Molecular Weight:239.12
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Yield:-
Reaction Conditions:
with chlorosulfonic acid in dichloromethane;
Steps:
5 B: 2,6-Dimethyl-4-chlorophenylsulfonyl chloride
B: 2,6-Dimethyl-4-chlorophenylsulfonyl chloride To 16.7 ml of chlorosulfonic acid at 10° C. was added 10.1 g of 3,5-dimethylchlorobenzene, (Example 5A), dropwise over a 10 minute period. The reaction was allowed to stir at about 10° C. for 90 minutes and then allowed to warm to room temperature and stirred overnight. The reaction was poured onto 150 g of ice, the solid that formed collected on a fritted glass funnel and dissolved in 150 ml of methylene chloride. The methylene chloride solution was washed with 70 ml of saturated sodium bicarbonate solution, dried with magnesium sulfate, filtered and concentrated to yield 13.5 g of the desired sulfonyl chloride. Using the procedure described in Example 5B, the following sulfonyl chlorides of Formula II were prepared from the indicated compounds: 2,4-dichloro-6-methoxybenzenesulfonyl chloride from 2,4-dichloroanisole and 2,5-dichloro-3,6-dimethylbenzenesulfonyl chloride from 2,5-dichloro-p-xylene.
References:
US5500405,1996,A
7758-89-6
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108-69-0
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