4-CHLORO-2,6-DIMETHYLPYRIMIDINE synthesis
- Product Name:4-CHLORO-2,6-DIMETHYLPYRIMIDINE
- CAS Number:4472-45-1
- Molecular formula:C6H7ClN2
- Molecular Weight:142.59
6622-92-0
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4472-45-1
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Yield: 82%
Reaction Conditions:
with trichlorophosphate in toluene for 3 h;Reflux;
Steps:
1.1.7. Preparation of 4-chloro-2,6-dimethylpyrimidine
POCl3 (0.460 g, 3.0 mmol) was added to the solution of compound 13 (1.0 mmol) in 15 mL of toluene and the mixture was stirred at reflux for 3 hours. Redundant POCl3 was removed under reduced pressure and ice water (10mL) was added. The solution was adjusted to the pH 9-10 with sodium carbonate and then extracted with methyl tert-butyl ether (MTBE). The organic phase was dried over sodium sulfate, and the solvent was removed under reduced pressure to afford compound 14. (Yield: 82%) MS (ESI) (m /z) [M+H]+ 143.1.
References:
Xu, Shaoyu;An, Baijiao;Li, Yuxin;Luo, Xunbang;Li, Xingshu;Jia, Xian [Bioorganic and Medicinal Chemistry Letters,2018,vol. 28,# 10,p. 1769 - 1775] Location in patent:supporting information
1780-26-3
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4472-45-1
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6622-92-0
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$9.00/1g
4472-45-1
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$8.00/250mg
930-62-1
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67-66-3
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4472-45-1
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95-89-6
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75712-74-2
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75712-73-1
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930-61-0
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67-66-3
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14331-54-5
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$32.00/250mg
123-32-0
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54198-89-9
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4472-45-1
171 suppliers
$8.00/250mg