ChemicalBook CAS DataBase List 4-CHLORO-2,6-DINITROPHENOL

4-CHLORO-2,6-DINITROPHENOL synthesis

10synthesis methods

Product Name:4-CHLORO-2,6-DINITROPHENOL
CAS Number:88-87-9
Molecular formula:C6H3ClN2O5
Molecular Weight:218.55

1679-18-1 Synthesis

1679-18-1
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88-87-9
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$144.00/25mg

Yield:88-87-9 81%

Reaction Conditions:

with dipotassium peroxodisulfate;copper(II) nitrate trihydrate in acetonitrile at 70; for 20 h;Inert atmosphere;Irradiation;Green chemistry;

Steps:

Polynitration; General Procedure
General procedure: A mixture of arylboronic acid 1 (1.0 equiv, 0.5 mmol), CuNO3·3H2O (3.0 equiv, 1.5 mmol) and K2S2O8 (3.0 equiv, 1.5 mmol) was added to a quartz reaction tube. Anhydrous MeCN (5 mL) was added under a nitrogen atmosphere. The mixture was stirred at 70 °C in a light reactor (WATTECS WP-VLH-1020 40 W blue LED) overnight. After the reaction was complete, the mixture was evaporated under reduced pressure to leave a crude residue, which was purified by column chromatography on silica gel (hexane/ethyl acetate = 8:1) to afford the product 2.

References:

Zhang, Qi;Raveendra Babu, Kaki;Huang, Zhouliang;Song, Jinna;Bi, Xihe [Synthesis,2018,vol. 50,# 15,art. no. SS-2018-C0119-ST,p. 2891 - 2896] Location in patent:supporting information

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