4-chloro-2-methoxy-6-nitroaniline synthesis
- Product Name:4-chloro-2-methoxy-6-nitroaniline
- CAS Number:859877-49-9
- Molecular formula:C7H7ClN2O3
- Molecular Weight:202.6
Yield:859877-49-9 46.4%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 2 h;
Steps:
20.2 Step 2. 4-Chloro-2-methoxy-6-nitroaniline.
Step 2. 4-Chloro-2-methoxy-6-nitroaniline. To a mixture of 2-amino-5- chloro-3-nitrophenol (752 mg, 4.0 mmol) and potassium carbonate (415 mg, 3.0 mmol) in DMF was added Mel (625 mg, 4.4 mmol). The reaction mixture was stirred at r.t. for 2hr, then quenched with water and extracted with EtOAc. Combined organic layers were washed with brine, dried over anhydrous Na2S04 and concentrated under reduced pressure. The residue was purified by flash column chromatography to give 4-chloro-2- methoxy- 6-nitroaniline (450 mg, 46.4% yield). LC-MS: m/z 203(M-H)+.
References:
WO2014/176258,2014,A1 Location in patent:Page/Page column 65
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