ChemicalBook CAS DataBase List 4-Chloro-2-nitrobenzoic acid

4-Chloro-2-nitrobenzoic acid synthesis

10synthesis methods

Product Name:4-Chloro-2-nitrobenzoic acid
CAS Number:6280-88-2
Molecular formula:C7H4ClNO4
Molecular Weight:201.56

74-11-3
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6280-88-2
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Yield:-

Reaction Conditions:

with nitric acid in water at 60; for 6 h;Cooling with ice;

Steps:

4.1.12. 3-(3-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-6,7-dimethoxyquinazolin-4(3H)-one (8a)
General procedure: To a 100 mL flask was added 3,4-dimethoxybenzoic acid (10 g,54.9 mmol) and nitric acid (50 mL, 20%) in an ice-bath. The reactionmixture was then stirred at 60 °C for 6 h. After cooling to rt, themixture was poured onto ice-water. The solid was filtered, washedwith water, dried. The crude was purified by a silica gel column toafford 2-nitro-4,5-dimethoxybenaoic acid as a light yellow solid(9.6 g, yield 77%). mp 195-197 °C; 1H NMR (CDCl3, ppm): d 7.42 (s,1H), 7.26 (s, 1H), 4.03 (s, 3H), 4.02 (s, 3H).

References:

Sun, Yu-Tong;Wang, Gui-Fei;Yang, Yi-Qiu;Jin, Fujun;Wang, Yifei;Xie, Xiao-Yang;Mach, Robert H.;Huang, Yun-Sheng [European Journal of Medicinal Chemistry,2018,vol. 147,p. 227 - 237]

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