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ChemicalBook CAS DataBase List 4-Chloro-3-hydroxybenzoyl chloride
888731-75-7

4-Chloro-3-hydroxybenzoyl chloride synthesis

2synthesis methods
34113-69-4 Synthesis
4-Chloro-3-hydroxybenzoic acid

34113-69-4
143 suppliers
$6.00/250mg

4-Chloro-3-hydroxybenzoyl chloride

888731-75-7
8 suppliers
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Yield:-

Reaction Conditions:

with thionyl chloride in N,N-dimethyl-formamide;toluene;

Steps:

R.41.1 Production of 4-chloro-3-hydroxybenzoyl chloride

Step 1 Production of 4-chloro-3-hydroxybenzoyl chloride 4-Chloro-3-hydroxybenzoic acid (510 mg) was suspended in toluene (6 mL), and thionyl chloride (0.28 mL) and N,N-dimethylformamide (1 drop) were added. After stirring with heating at 70° C. for 2 hrs, and the mixture was concentrated and azeotroped with toluene to give the title compound.

References:

US2008/305169,2008,A1