ChemicalBook CAS DataBase List 4-CHLORO-3-NITROBENZAMIDE

4-CHLORO-3-NITROBENZAMIDE synthesis

9synthesis methods

Product Name:4-CHLORO-3-NITROBENZAMIDE
CAS Number:16588-06-0
Molecular formula:C7H5ClN2O3
Molecular Weight:200.58

14719-83-6
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$5.00/1g

16588-06-0
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$17.00/1g

Yield: 86%

Reaction Conditions:

with ammonium hydroxide at 30; for 15 h;Inert atmosphere;Temperature;

Steps:

1; 39; 79 Synthesis of compound 1.5
Into a 250-mL 3-necked round-bottom flask purged and maintained with an inert atmosphere of argon, was placed 1.4 (5 g, 23.0 mmol, 1.00 eq) and ammonia (50 mL). The reaction was stirred for 15 h at 30°C in an oil bath. The solids were collected by filtration. The mixture was concentrated under vacuum to yield 4.0 g (86.0%) of 1.5 as an off-white solid. (ES, m/z): 199 (M-H)'.

References:

NIMBUS TITAN, INC.;LEIT DE MORADEI, Silvana Marcel;ROMERO, Donna L.;KNIGHT, Jennifer;CLARK, Anthony;BOS, Pieter WO2020/132582, 2020, A1 Location in patent:Paragraph 00369; 00546; 00696