4-CHLORO-3-NITROBENZANILIDE synthesis
- Product Name:4-CHLORO-3-NITROBENZANILIDE
- CAS Number:41614-16-8
- Molecular formula:C13H9ClN2O3
- Molecular Weight:276.68
Yield:41614-16-8 97%
Reaction Conditions:
with thionyl chloride in chlorobenzene at 70 - 100; for 2 h;Large scale;Green chemistry;Reagent/catalyst;Solvent;Temperature;
Steps:
2.1 (1) Preparation of 3-nitro-4-chlorobenzanilide:
In a 1000L reaction container, pump chlorobenzene (200 kg), aniline (27 kg). Start stirring. Add 3-nitro-4-chlorobenzoic acid (50 kg, folding one hundred). Heat to 70-80 deg.C. Add dropwise thionyl chloride (40 kg). After dropwise addition, heat to 100 deg.C. Maintain temperature for 2 hours. Cool to room temperature, drop watering (400 kg), heating to reflux, the reflux for the distillation, atmospheric boil off paradichlorbenzene rear, cooling, filtering, drying shall be 3-nitro-4-chlorobenzanilide 66.5 kg, the cinnamon solid, purity of 98.5%, the yield is 97%
References:
CN105753731,2016,A Location in patent:Paragraph 0018
62-53-3
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