4-CHLORO-4'-METHOXYBIPHENYL synthesis

13synthesis methods

Product Name:4-CHLORO-4'-METHOXYBIPHENYL
CAS Number:58970-19-7
Molecular formula:C13H11ClO
Molecular Weight:218.68

637-87-6
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$38.00/10g

5720-07-0 Synthesis

5720-07-0
457 suppliers
$6.00/5g

58970-19-7
34 suppliers
$209.00/1g

Yield:58970-19-7 98%

Reaction Conditions:

with potassium carbonate in ethanol;water at 50; for 1 h;Suzuki-Miyaura Coupling;

Steps:

2.4.1 Suzuki Cross-Coupling Reaction

General procedure: A flame-dried 50mL round-bottom flask equipped with amagnetic stir bar and a rubber septum was charged with arylhalide (1.0mmol), phenyl boronic acid (1.1mmol), K2CO3(2.0mmol) and CL-salen-Pd(II) (0.5% mmol). The mixturewas stirred in Ethanol: H2O= 1:1 (5.0mL) at 50 underair atmosphere for 1h. The mixture was cooled to roomtemperature, quenched with water (5mL), and diluted withethyl acetate (5mL). The layers were separated, and theaqueous layer was extracted with 2 × 5mL of ethyl acetate.The combined organic extracts were dried over anhydrousmagnesium sulfate, filtered, and concentrated in vacuo.Finally, the product was purified by column chromatography.

References:

Sun, Peng;Yang, Jiaojiao;Chen, Chunxia;Xie, Kaijun;Peng, Jinsong [Catalysis Letters,2020,vol. 150,# 10,p. 2900 - 2910]

623-12-1 Synthesis