![](/CAS/GIF/941294-43-5.gif)
4-Chloro-6-(cyclopropylamino)pyrimidine synthesis
- Product Name:4-Chloro-6-(cyclopropylamino)pyrimidine
- CAS Number:941294-43-5
- Molecular formula:C7H8ClN3
- Molecular Weight:169.61
![4,6-Dichloropyrimidine](/CAS/GIF/1193-21-1.gif)
1193-21-1
552 suppliers
$14.00/5g
![Cyclopropylamine](/CAS/GIF/765-30-0.gif)
765-30-0
486 suppliers
$10.00/25g
![4-Chloro-6-(cyclopropylamino)pyrimidine](/CAS/GIF/941294-43-5.gif)
941294-43-5
44 suppliers
$70.00/250mg
Yield:941294-43-5 16.7%
Reaction Conditions:
in isopropyl alcohol at 20; for 4 h;
Steps:
1.4 6-Chloro-N-cyclopropylpyrimidin-4-amine
4,6-Dichloropyrimidine 1f (10.0 g, 67.12 mmol) was dissolved in 50 mL of isopropanol, 1 g (3.48 g, 67.12 mmol) of cyclopropylamine was added and the mixture was reacted at room temperature for 4 hours.The reaction solution was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent: System C) to give 6-chloro-N-cyclopropylpyrimidin-4-amine 1h (1.90 g, white powder) Yield: 16.7%
References:
CN107400092,2017,A Location in patent:Paragraph 0169; 0171; 0185-0187