4-CHLORO-N,N-DIMETHYL-PYRIDINE-2-CARBOXAMIDE synthesis
- Product Name:4-CHLORO-N,N-DIMETHYL-PYRIDINE-2-CARBOXAMIDE
- CAS Number:114780-06-2
- Molecular formula:C8H9ClN2O
- Molecular Weight:184.62
53750-66-6
94 suppliers
$60.00/250 mg
124-40-3
510 suppliers
$18.00/100ml
114780-06-2
60 suppliers
inquiry
Yield:-
Reaction Conditions:
with triethylamine in tetrahydrofuran;dichloromethane at 0 - 20;
Steps:
822.1 Step 1. Synthesis of 4-Chloro-pyridine-2-carboxylic acid dimethylamide
Step 1.Synthesis of 4-Chloro-pyridine-2-carboxylic acid dimethylamide: A solution of 4-chloro-pyridine-2-carbonyl chloride (1 eq) in dichloromethane was cooled to 0° C., whereupon triethylamine (2 eq) was added followed by dimethylamine (2 eq, 2M solution in THF).The solution was allowed to warm to room temperature and let stir overnight.It was then washed with 1M NaOH. The separated organic layer is dried over MgSO4, filtered, and concentrated to yield the desired product. HPLC, 1.82 min; MS: MH+=185.6
References:
Amiri, Payman;Fantl, Wendy;Levine, Barry Haskell;Poon, Daniel J.;Ramurthy, Savithri;Renhowe, Paul A.;Subramanian, Sharadha;Sung, Leonard US2004/122237, 2004, A1 Location in patent:Page 248
220000-87-3
475 suppliers
$8.00/5g
74-88-4
348 suppliers
$15.00/10g
114780-06-2
60 suppliers
inquiry
98-98-6
614 suppliers
$5.00/10g
114780-06-2
60 suppliers
inquiry