4-chlorobenzo[4,5]thieno[2,3-d]pyriMidine synthesis

7synthesis methods

Product Name:4-chlorobenzo[4,5]thieno[2,3-d]pyriMidine
CAS Number:40142-92-5
Molecular formula:C10H5ClN2S
Molecular Weight:220.68

18774-49-7 Synthesis

18774-49-7
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4-chlorobenzo[4,5]thieno[2,3-d]pyriMidine

40142-92-5
9 suppliers
$285.00/100mg

Yield:40142-92-5 74%

Reaction Conditions:

with trichlorophosphateReflux;

Steps:

S.8 General method for the preparation of 4-chloro-thieno[2,3-d]pyrimidines 7a-d, f-i

General procedure: The different thieno[2,3-d]pyrimidin-4-one (6a-d or f-i) (1 eq.) and phosphoryl chloride (2.9 mL/mmoleq.) were refluxed for 8 h. The reaction mixture was then cooled in an ice-bath and carefully neutralised by the addition of aqueous saturated NaHCO3 solution. The resulting mixture was extracted with ethylacetate (15 mL/mmol eq.), the organic layer was separated, dried over MgSO4 and concentrated. The crude residue was purified by flash column chromatography eluting with n-hexane-EtOAc 100:0 v/vincreasing to n-hexane-EtOAc 85:15 v/v unless otherwise stated.

References:

Bassetto, Marcella;Leyssen, Pieter;Neyts, Johan;Yerukhimovich, Mark M.;Frick, David N.;Brancale, Andrea [European Journal of Medicinal Chemistry,2016,vol. 123,p. 31 - 47] Location in patent:supporting information

18774-49-7 Synthesis

18774-49-7
12 suppliers
inquiry

40142-92-5
9 suppliers
$285.00/100mg

References

ETHYL-2-AMINO-BENZO(B)THIOPHENE-3-CARBOXYLATE

7311-95-7
71 suppliers
$89.00/100mg

40142-92-5
9 suppliers
$285.00/100mg

References

4506-71-2 Synthesis

ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE

4506-71-2
200 suppliers
$6.00/1g

40142-92-5
9 suppliers
$285.00/100mg

References

108-94-1 Synthesis

108-94-1
527 suppliers
$12.00/50g

40142-92-5
9 suppliers
$285.00/100mg

References