ChemicalBook CAS DataBase List 4-chlorobenzo[4,5]thieno[3,2-d]pyrimidine

4-chlorobenzo[4,5]thieno[3,2-d]pyrimidine synthesis

6synthesis methods

Product Name:4-chlorobenzo[4,5]thieno[3,2-d]pyrimidine
CAS Number:36822-09-0
Molecular formula:C10H5ClN2S
Molecular Weight:220.68

36822-08-9 Synthesis

3H-BENZO[4,5]THIENO[3,2-D]PYRIMIDIN-4-ONE

36822-08-9
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4-chlorobenzo[4,5]thieno[3,2-d]pyrimidine

36822-09-0
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Yield:36822-09-0 99%

Reaction Conditions:

with N,N-dimethyl-formamide;trichlorophosphate at 110; for 5 h;Inert atmosphere;

Steps:

2.3 Step 3: Synthesis of 4-chloro-3,4-dihydrobenzo[4,5]thiophene[3,2-d]pyrimidine

Dissolve benzo[4,5]thiophene[3,2-d]pyrimidin-4(3H)-one (4.38g, 21.6mmol) in 25mL of phosphorus oxychloride,Add two drops of N,N-dimethylformamide as a catalyst, heat to 110°C and reflux until the reaction is complete, about 5 hours (TLC monitoring).Cool the system to room temperature, slowly pour it into ice water, and neutralize it with sodium hydroxide to a pH of 8-9,Then the aqueous phase was extracted 3 times with ethyl acetate, the organic phases were combined, dried, and rotary evaporated.Separation by silica gel column chromatography (eluent: ethyl acetate: petroleum ether = 1:100, v/v),The white solid product 4-chloro-3,4-dihydrobenzo[4,5]thiophene[3,2-d]pyrimidine (4.75g, 99%) was obtained.

References:

CN111440216,2020,A Location in patent:Paragraph 0141; 0148-0150

36822-08-9 Synthesis

36822-08-9
34 suppliers
$41.00/100mg

36822-09-0
18 suppliers
inquiry

References

34761-09-6 Synthesis