(4-Chlorobenzoyl)benzofuran synthesis
- Product Name:(4-Chlorobenzoyl)benzofuran
- CAS Number:27052-20-6
- Molecular formula:C15H9ClO2
- Molecular Weight:256.68
Yield:27052-20-6 99%
Reaction Conditions:
with (phthalocyaninato)iron(II);potassium carbonate in tetrahydrofuran at 100; for 18 h;Schlenk technique;Reagent/catalyst;Solvent;Temperature;
Steps:
1-21; 1-12 General steps:
General procedure: In a dry Schlenk tube, add salicylaldehyde derivative (0.2 mmol), sulfur ylide (0.24 mmol), FeIIPc (10 mol%), K2CO3 (2.0 eq), THF (2.0 mL). Then, the reaction mixture was placed in an oil bath at 100°C and stirred for 18 hours. After the reaction, the reaction was followed by TLC or GC-MS, cooled to room temperature, and an appropriate amount of ethyl acetate was added for washing. The organic phase was evaporated by rotary evaporation. Distill under reduced pressure, use 100-200 mesh silica gel to mix the sample, use 200-300 mesh or 300-400 mesh silica gel column chromatography, dry the sample, ethyl acetate: petroleum ether = 1:20 elution, and concentrate to obtain the target product.
References:
CN112812084,2021,A Location in patent:Paragraph 0053-0060
