4-Chloroquinazoline-6-carbaldehyde synthesis

Yield:648449-05-2 88%

Reaction Conditions:

with Dess-Martin periodane in dichloromethane at 20; for 0.5 h;

Steps:

12.II Step [II] : [4-CHLOROQUINAZOLINE-6-CARBOXALDEHYDE]

To a solution of [4-CHLOROQUINAZOLINE-6-YL-METHANOL] (3. 5g, [0.] [01 8MOL)] in dry [CH2CL2] [(LOOML)] was added Dess-Martin periodinane (8.4g, 0. [019MOL)] and stirred at RT for 30min. The reaction mixture was washed with 10% aqueous [NAHC03] [(75ML),] water, brine and dried. The solvent was removed under vacuum to give 4-chloroquinazoline-6- carboxaldehyde (3g, [88%)] as pale yellow solid. TLC, [CHLOROFORM/METHANOL,] 9: 1, [RR0.]

References:

WO2004/7491,2004,A1 Location in patent:Page 60