ChemicalBook CAS DataBase List Thieno[3,2-d]pyrimidine-7-carboxylic acid, 4-chloro-

Thieno[3,2-d]pyrimidine-7-carboxylic acid, 4-chloro- synthesis

10synthesis methods

Product Name:Thieno[3,2-d]pyrimidine-7-carboxylic acid, 4-chloro-
CAS Number:1269667-57-3
Molecular formula:C7H3ClN2O2S
Molecular Weight:214.63

methyl 4-chlorothieno[3,2-d]pyrimidine-7-carboxylate

1246223-44-8
24 suppliers
$45.00/10mg

Thieno[3,2-d]pyrimidine-7-carboxylic acid, 4-chloro-

1269667-57-3
26 suppliers
$45.00/5mg

Yield: 81%

Reaction Conditions:

with lithium hydroxide monohydrate;water in tetrahydrofuran at 20; for 2 h;

Steps:

8.A
To a solution of methyl 4-chlorothieno[3,2-d]pyrimidine-7-carboxylate (2.00 g, 8.75 mmol) in tetrahydrofuran (60 mL) and water (20 mL) was added lithium hydroxide monohydrate (0.59 g, 14.0 mmol). The reaction mixture was stirred at room temperature for 2 hours, after which the volatiles were concentrated in vacuo. Water was added and a solid was obtain after filtration, which was rinsed with water and dried on a lyophilizer to afford 4-chlorothieno[3,2-fiT]pyrimidine-7-carboxylic acid (1.56 g, 81%).

References:

ARRAY BIOPHARMA INC.;GENENTECH, INC.;ALIAGAS, Ignacio;GRADL, Stefan;GUNZNER, Janet;MATHIEU, Simon;PULK, Rebecca;RUDOLPH, Joachim;WEN, Zhaoyang;GRINA, Jonas;HANSEN, Joshua D.;LAIRD, Ellen;MORENO, David;REN, Li;WENGLOWSKY, Steven Mark WO2011/25940, 2011, A1 Location in patent:Page/Page column 96

4-chlorothieno[3,2-d]pyrimidine-7-carbaldehyde

1318133-04-8
3 suppliers
inquiry

1269667-57-3
26 suppliers
$45.00/5mg

References

16234-10-9
133 suppliers
$14.00/1g

1269667-57-3
26 suppliers
$45.00/5mg

References

31169-25-2
95 suppliers
$55.00/50mg

1269667-57-3
26 suppliers
$45.00/5mg

References

85006-31-1 Synthesis

Methyl 3-amino-4-methylthiophene-2-carboxylate

85006-31-1
358 suppliers
$5.00/5g

1269667-57-3
26 suppliers
$45.00/5mg

References