4-(DIFLUOROMETHYL)BENZOIC ACID synthesis

7synthesis methods

Product Name:4-(DIFLUOROMETHYL)BENZOIC ACID
CAS Number:55805-21-5
Molecular formula:C8H6F2O2
Molecular Weight:172.13

444915-76-8 Synthesis

444915-76-8
23 suppliers
$65.00/100mg

55805-21-5
44 suppliers
$45.00/250 mg

Yield: 98%

Reaction Conditions:

with lithium hydroxide monohydrate;water in tetrahydrofuran at 20; for 3 h;Inert atmosphere;

Steps:

34.B
[00227] Step B: A mixture of methyl 4-(difluoromethyl)benzoate (1.1 g, 5.9 mmol) and LiOH H₂0 (1.24 g, 29.5 mmol) in THF/H₂0 (30/10 mL) was stirred at room temperature for 3 hours. The mixture was acidified by IN HC1 to a pH of 2 and extracted with EtOAc. The organic layer was washed with water and brine, dried over Na₂S0₄, filtered and concentrated to give 4-(difluoromethyl)benzoic acid (1.0 g, 98.0% yield).

References:

ARRAY BIOPHARMA INC.;GENENTECH, INC.;HICKEN, Erik James;HUNT, Kevin W.;RODRIGUEZ, Martha E.;TANG, Tony P.;SIU, Michael WO2013/148851, 2013, A1 Location in patent:Paragraph 00227

55805-10-2 Synthesis