4-(DIFLUOROMETHYL)BENZOIC ACID synthesis
- Product Name:4-(DIFLUOROMETHYL)BENZOIC ACID
- CAS Number:55805-21-5
- Molecular formula:C8H6F2O2
- Molecular Weight:172.13
444915-76-8
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$65.00/100mg
55805-21-5
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$45.00/250 mg
Yield: 98%
Reaction Conditions:
with lithium hydroxide monohydrate;water in tetrahydrofuran at 20; for 3 h;Inert atmosphere;
Steps:
34.B
[00227] Step B: A mixture of methyl 4-(difluoromethyl)benzoate (1.1 g, 5.9 mmol) and LiOH H20 (1.24 g, 29.5 mmol) in THF/H20 (30/10 mL) was stirred at room temperature for 3 hours. The mixture was acidified by IN HC1 to a pH of 2 and extracted with EtOAc. The organic layer was washed with water and brine, dried over Na2S04, filtered and concentrated to give 4-(difluoromethyl)benzoic acid (1.0 g, 98.0% yield).
References:
ARRAY BIOPHARMA INC.;GENENTECH, INC.;HICKEN, Erik James;HUNT, Kevin W.;RODRIGUEZ, Martha E.;TANG, Tony P.;SIU, Michael WO2013/148851, 2013, A1 Location in patent:Paragraph 00227
55805-10-2
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55805-21-5
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99-94-5
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$9.00/1g
55805-21-5
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$45.00/250 mg
1309-60-0
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$15.00/25G
99-94-5
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55805-21-5
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$45.00/250 mg
105-07-7
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$5.00/5g
55805-21-5
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$45.00/250 mg