ChemicalBook CAS DataBase List 4-DIMETHYLAMINOBUTYRIC ACID HYDROCHLORIDE

4-DIMETHYLAMINOBUTYRIC ACID HYDROCHLORIDE synthesis

6synthesis methods

Product Name:4-DIMETHYLAMINOBUTYRIC ACID HYDROCHLORIDE
CAS Number:69954-66-1
Molecular formula:C6H14ClNO2
Molecular Weight:167.63

50-00-0 Synthesis

50-00-0
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56-12-2 Synthesis

56-12-2
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$5.00/100mg

4-DIMETHYLAMINOBUTYRIC ACID HYDROCHLORIDE

69954-66-1
114 suppliers
$44.50/5g

Yield:-

Reaction Conditions:

with formic acid for 16 h;Reflux;Inert atmosphere;

Steps:

4-(Dimethylamino)butanoic acid-HCl
γ-Aminobutyric acid (1.00 g, 9.69 mmol) was dissolved in 90% formic acid (2.52 mL) and 37% formaldehyde (1.94 mL) and refluxed for 16 hrs. The resulting solution was cooled, acidified with cone. HC1, and evaporated to dryness. The resulting solid was azeotroped with toluene several times to remove all traces of formic acid. The solid was then recrystallized from acetonitrile to yield 4- (dimethylamino)butanoic acid as the HC1 salt, mp 148-149 °C.

References:

UNIVERSITY OF CONNECTICUT;BALUNAS, Marcy J.;PAVLIK, Christopher M.;GERWICK, William H. WO2014/18913, 2014, A2 Location in patent:Page/Page column 48

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