![](/CAS/GIF/202522-22-3.gif)
4-FLUORO-2-(TRIFLUOROMETHYL)BENZYLAMINE synthesis
- Product Name:4-FLUORO-2-(TRIFLUOROMETHYL)BENZYLAMINE
- CAS Number:202522-22-3
- Molecular formula:C8H7F4N
- Molecular Weight:193.14
![4-Fluoro-2-trifluoromethylbenzonitrile](/CAS/GIF/194853-86-6.gif)
194853-86-6
234 suppliers
$6.00/5g
![4-FLUORO-2-(TRIFLUOROMETHYL)BENZYLAMINE](/CAS/GIF/202522-22-3.gif)
202522-22-3
98 suppliers
$15.00/1g
Yield:-
Reaction Conditions:
with hydrogen;Raney Ni in ethanol under 2585.81 Torr;
Steps:
45
(4-Fluoro-2-(trifluoromethyl)phenyl)methanamine To a solution of 4-fluoro-2-(trifluoromethyl)benzonitrile (2.0 g) in ethanol (10.0 mL) was added Raney Ni (catalytic amount). The reaction mixture was subjected for hydrogenation in Parr apparatus under 50 psi for 2-3 h. The reaction mass filtered through celite and concentrated the filtrate to afford 0.400 g of the desired product. 1HNMR (CDCl3): δ 3.98 (s, 2H), 7.24 (t, J=9.0 Hz, 1H), 7.34 (d, J=8.7 Hz, 1H), 7.54 (t, J=7.8 Hz, 1H); MS [M+H]+: 194.03.
References:
Glenmark Pharmaceuticals S.A. US2012/108583, 2012, A1 Location in patent:Page/Page column 36