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2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE synthesis
- Product Name:2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE
- CAS Number:239087-06-0
- Molecular formula:C8H7F4N
- Molecular Weight:193.14
![2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE](/CAS/GIF/60611-24-7.gif)
60611-24-7
198 suppliers
$10.00/1g
![2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE](/CAS/GIF/239087-06-0.gif)
239087-06-0
178 suppliers
$14.00/100mg
Yield:239087-06-0 95%
Reaction Conditions:
Stage #1:2-fluoro-6-(trifluoromethyl)benzaldehyde with hydroxylamine hydrochloride;sodium hydroxide in ethanol;water for 1 h;
Stage #2: with hydrogenchloride;zinc in ethanol;water for 2 h;
Steps:
11-12 Example 12Preparation of 2-fluoro-6-trifluoromethylbenzylamine E6
Add 250 g of hydroxylamine hydrochloride and 50 ml of water to a 250 ml three-necked bottle.The aqueous phase was adjusted to neutrality with 10% sodium hydroxide, and then the ethanol solution of E5 (5g / 20ml) was slowly added dropwise. After stirring for 1h, 6g of zinc powder was added in batches.Hydrochloric acid (6 mol / L, 40 ml) was added dropwise. After 2 hours of reaction, the mixture was filtered, and 50 ml of ammonia was added to the filtrate.Adjust the pH to 11 with 6 ml of 33% sodium hydroxide, and extract with dichloromethane.The organic phase was collected, washed with saturated brine, and dried over anhydrous sodium sulfate.Suctioned and concentrated to give 4.78 g of yellow oil(95% yield).
References:
Shanghai Pharmaceutical Industry Institute;China Pharmaceutical Industry Zongyuan;Liu Yanming;Hao Qun;Lin Kuaile;Zhou Weicheng;Pan Jing;Chen Liang;Zhou Ting CN110498771, 2019, A Location in patent:Paragraph 0133-0136
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133116-83-3
208 suppliers
$8.00/1g
![2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE](/CAS/GIF/239087-06-0.gif)
239087-06-0
178 suppliers
$14.00/100mg
![Benzaldehyde, 2-fluoro-6-(trifluoromethyl)-, oxime](/CAS/20200401/GIF/581072-15-3.gif)
581072-15-3
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inquiry
![2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE](/CAS/GIF/239087-06-0.gif)
239087-06-0
178 suppliers
$14.00/100mg
![3-Fluorobenzotrifluoride](/CAS/GIF/401-80-9.gif)
401-80-9
306 suppliers
$5.00/10g
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239087-06-0
178 suppliers
$14.00/100mg
![2-FLUORO-6-(TRIFLUOROMETHYL)BENZOIC ACID](/CAS/GIF/32890-94-1.gif)
32890-94-1
138 suppliers
$12.00/1g
![2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE](/CAS/GIF/239087-06-0.gif)
239087-06-0
178 suppliers
$14.00/100mg